ROR1 is a pseudokinase that is crucial for MET-driven tumorigenesis
نویسندگان
چکیده
منابع مشابه
Tumor and Stem Cell Biology Ror1 Is a Pseudokinase That Is Crucial for Met-Driven Tumorigenesis
The human kinome includes Ror1, a poorly characterized orphan receptor. Here we report the findings of an investigation of Ror1 contributions to cancer, undertaken through an integrated screening of 43 cancer cell lines where we measured protein expression, tyrosine phosphorylation, and growth response following RNAimediated Ror1 suppression. Ror1 was expressed in approximately 75% of the cance...
متن کاملROR1 is a pseudokinase that is crucial for MET-driven tumorigenesis
The human kinome includes Ror1, a poorly characterized orphan receptor. Here we report the findings of an investigation of Ror1 contributions to cancer, undertaken through an integrated screening of 43 cancer cell lines where we measured protein expression, tyrosine phosphorylation, and growth response following RNAi-mediated Ror1 suppression. Ror1 was expressed in approximately 75% of the canc...
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Cell multiplication in the absence of integrin-derived adhesive signals (anchorage-independent growth) is the phenotypic hallmark of neoplastic transformation. Therefore, the frequently observed up-regulation of some integrins in tumors has been interpreted as an epiphenomenon and not as a causative factor of oncogenic conversion. B4 integrin stimulates proliferation and survival of epithelial ...
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Cell multiplication in the absence of integrin-derived adhesive signals (anchorage-independent growth) is the phenotypic hallmark of neoplastic transformation. Therefore, the frequently observed up-regulation of some integrins in tumors has been interpreted as an epiphenomenon and not as a causative factor of oncogenic conversion. beta4 integrin stimulates proliferation and survival of epitheli...
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ژورنال
عنوان ژورنال: BMC Proceedings
سال: 2013
ISSN: 1753-6561
DOI: 10.1186/1753-6561-7-s2-p43